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RESEARCH PRODUCT
Subtle retinal pathology in amyotrophic lateral sclerosis
Axel MethnerMartin SüdmeyerMarius RingelsteinPhilipp AlbrechtNazmiye KeserOrhan AktasStefano FerreaAlfons SchnitzlerJens HarmelDavid FinisRainer GuthoffHans-peter HartungAnn-kristin Müllersubject
Pathologymedicine.medical_specialtymedicine.diagnostic_testgenetic structuresbusiness.industryGeneral NeuroscienceNeurodegenerationNerve fiber layerRetinalmedicine.diseaseeye diseaseschemistry.chemical_compoundmedicine.anatomical_structurechemistryOptical coherence tomographyMotor systemDecreased Visual AcuityInner nuclear layermedicineNeurology (clinical)sense organsAmyotrophic lateral sclerosisbusinessBrief Communicationsdescription
Amyotrophic lateral sclerosis (ALS) is characterized by neuro-ophthalmological abnormalities beyond disturbed oculomotor control such as decreased visual acuity and disturbed visual evoked potentials. Here we report retinal alterations in a cohort of 24 patients with clinically definite (n = 20) or probable (n = 4) ALS as compared to matched controls. High-resolution spectral domain optical coherence tomography with retinal segmentation revealed a subtle reduction in the macular thickness and the retinal nerve fiber layer (RNFL) as well as a marked thinning of the inner nuclear layer (INL). Our data indicate an unprecedented retinal damage pattern and suggest neurodegeneration beyond the motor system in this disease.
year | journal | country | edition | language |
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2014-03-01 | Annals of Clinical and Translational Neurology |