6533b858fe1ef96bd12b641d

RESEARCH PRODUCT

Increase of CCR7- CD45RA+ CD8 T cells (TEMRA) in Chronic Graft-versus-host Disease

F PorrettoFrancesco DieliM. D'asaroAlfredo SalernoM MussoNadia Caccamo

subject

AdultCancer ResearchReceptors CCR7Allogeneic transplantationmedicine.medical_treatmentGraft vs Host DiseaseC-C chemokine receptor type 7DiseaseHematopoietic stem cell transplantationCD8-Positive T-LymphocytesCCR7 CD45RA CD8Quality of lifemedicineCytotoxic T cellHumansLymphocyte CountAutoimmune diseasebusiness.industryHematologymedicine.diseasesurgical procedures operativeGraft-versus-host diseaseOncologyImmunologyChronic DiseaseLeukocyte Common AntigensReceptors ChemokinebusinessImmunologic Memory

description

Among the late effects of hematopoietic stem cell transplantation (HSCT), chronic graft-vs-host disease (cGVHD) still remains as the major determinant of long-term outcome and quality of life. The disease typically appears between 3 months to 1.5 years following an allogeneic transplantation and is characterized by symptoms similar to those of autoimmune disease.

yearjournalcountryeditionlanguage
2006-01-13
10.1038/sj.leu.2404079http://hdl.handle.net/10447/2304