6533b858fe1ef96bd12b6579
RESEARCH PRODUCT
Investigations on the geographical variability of the human transferrins.
M. BajatzadehH. Waltersubject
chemistry.chemical_classificationGeneticsPhysiological functionTropical ClimateNative Hawaiian or Other Pacific IslanderGeographyRacial GroupsTransferrinBlack PeopleGenetic VariationBiologyWhite PeopleGenetics PopulationCharacteristic distributionchemistryAsian PeopleEvolutionary biologyTransferrinInuitGeneticsHumansAlleleAdaptationGenetics (clinical)Allelesdescription
On the basis of own and from the widely scattered literature compiled materials the geographical distribution of the transferrin alleles is discussed. They reveal a characteristic distribution pattern, as the slow Tf variants produced by TfD alleles are obviously more frequent in tropical than in non-tropical populations. Considering similar results in cattle and its interpretation by Ashton (1958, 1965), it is hypothesized, that the relatively high TfΓ frequencies in tropical biotops might be a selective adaptation to their special climatic conditions. In this connection an association between slowly moving transferrin proteins in man and tolerance to hotter climates — as could be found in cattle — is supposed. Further studies on the physiological function of the human transferrin and particularly of its various variants are necessary, however, either to prove or to reject our hypothesis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1971-01-01 | Humangenetik |