6533b859fe1ef96bd12b6f10
RESEARCH PRODUCT
Comparison of iodinated contrast media for the assessment of atherosclerotic plaque attenuation values by CT coronary angiography: observations in an ex vivo model
Ludovico La GruttaMassimo GaliaGiovanni Domenico GentileGiuseppe Lo ReEmanuele GrassedonioF CoppolinoE MaffeiEmiliano MaresiAntonio Lo CastoF CademartiriMassimo MidiriGiuseppe Lo Resubject
Malemedicine.medical_specialtySerial dilutionmedicine.medical_treatmentContrast MediaCoronary Artery Diseaseatherosclerotic plaqueIn Vitro TechniquesCoronary AngiographySensitivity and SpecificityIopamidolCoronary artery diseaseCT Coronary AngiographyTriiodobenzoic AcidsMedicineHumansRadiology Nuclear Medicine and imagingSalineFull PaperDose-Response Relationship Drugex-vivo modelbusiness.industryAttenuationReproducibility of ResultsGeneral MedicineMiddle Agedmedicine.diseaseIopamidolCoronary arteriesContrast mediummedicine.anatomical_structureIodinated contrast mediaFemaleRadiologySettore MED/36 - Diagnostica Per Immagini E RadioterapiabusinessTomography X-Ray ComputedEx vivomedicine.drugdescription
Objective: To compare the influence of different iodinated contrast media with several dilutions on plaque attenuation in an ex vivo coronary model studied by multislice CT coronary angiography. Methods: In six ex vivo left anterior descending coronary arteries immersed in oil, CT (slices/collimation 64x0.625 mm, temporal resolution 210 ms, pitch 0.2) was performed after intracoronary injection of a saline solution, and solutions of a dimeric isosmolar contrast medium (Iodixanol 320 mgl ml(-1)) and a monomeric high-iodinated contrast medium (Iomeprol 400 mgl ml(-1)) with dilutions of 1/80 (low concentration), 1/50 (medium concentration), 1/40 (high concentration) and 1/20 (very high concentration). Two radiologists drew regions of interest in the lumen and in calcified and non-calcified plaques for each solution. 29 cross-sections with non-calcified plaques and 32 cross-sections with calcified plaques were evaluated. Results: Both contrast media showed different attenuation values within lumen and plaque (p 0.05). Conclusion: Differently iodinated contrast media have a similar influence on plaque attenuation profiles. Advances in knowledge: Since iodine load affects coronary plaque attenuation linearly, different contrast media may be equally employed for coronary atherosclerotic plaque imaging.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 |