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RESEARCH PRODUCT

Social Interactions of Dat-Het Epi-Genotypes Differing for Maternal Origins: The Development of a New Preclinical Model of Socio-Sexual Apathy

Giovanni LaviolaSilvia ZelliCristiana CarboneWalter AdrianiWalter AdrianiAnna Sara LiberatiAnna EbrancatoCarla CannizzaroSara Lucia Maria Lo Russo

subject

animal structuresOffspringQH301-705.5socio-sexual rewardMedicine (miscellaneous)PhysiologyHippocampusArticleGeneral Biochemistry Genetics and Molecular Biologysocial behavior03 medical and health sciences0302 clinical medicineGenetic predispositionAlleleBiology (General)Prefrontal cortexdopamine transporterDopamine transporterEstrous cyclebiologyapplied_psychology030227 psychiatrySettore BIO/14 - Farmacologiabiology.proteinparent-of-origin effectAbnormality030217 neurology & neurosurgery

description

Social interaction is essential for life but is impaired in many psychiatric disorders. We presently focus on rats with a truncated allele for dopamine transporter (DAT). Since heterozygous individuals possess only one non-mutant allele, epigenetic interactions may unmask latent genetic predispositions. Homogeneous “maternal” heterozygous offspring (termed MAT-HET) were born from dopamine-transporter knocked-out (DAT-KO) male rats and wild-type (WT) mothers

yearjournalcountryeditionlanguage
2021-07-01Biomedicines
10.3390/biomedicines9070778https://www.mdpi.com/2227-9059/9/7/778