6533b859fe1ef96bd12b787e

RESEARCH PRODUCT

JC Virus and Lung Adenocarcinoma: Fact or Myth?

Mario StellaGiuseppe FerraraElena GalloDario RaimondoGiovanni TomaselloEmanuele SinagraMassimiliano SpadaMario CottoneAroldo RizzoMarco MessinaFrancesca Rossi

subject

0301 basic medicineMaleCancer ResearchPathologymedicine.medical_specialtyTumor Virus InfectionsLung NeoplasmsvirusesJC virusAdenocarcinoma of Lung030230 surgeryAdenocarcinomamedicine.disease_causePolymerase Chain ReactionVirus03 medical and health sciences0302 clinical medicinemedicineHumansLung cancerAgedPolyomavirus InfectionsLungbusiness.industryJC Virus InfectionGeneral Medicinemedicine.diseaseJC VirusTumor Virus Infections030104 developmental biologymedicine.anatomical_structureOncologyCase-Control StudiesLymphatic MetastasisDNA ViralAdenocarcinomaFemalebusinessPolyomavirus Infections

description

Background/aim An association has been reported between lung cancer and John Cunningham (JC) virus infection. The aim of this study was to evaluate the prevalence of JC virus in a small cohort of patients with lung adenocarcinoma and assess its presence in nodal metastasis. Materials and methods Consecutive samples of 13 surgically-removed lung tumors and 13 surrounding normal cancer-free tissues were selected. Five cases included metastatic lymph nodes. JC virus infection was assessed through nested PCR. Results Seven out of thirteen patients with lung adenocarcinoma had a positive PCR test for JC virus. One of the five patients with nodal metastasis had a positive PCR test for JC virus. None of the thirteen specimens from the control group presented with JC virus infection. The difference between the two groups regarding JC virus infection was statistically significant (p=0.008). Conclusion Our study suggests that JC virus might be involved in lung carcinogenesis.

yearjournalcountryeditionlanguage
2017-05-29Anticancer research
10.21873/anticanres.11699https://pubmed.ncbi.nlm.nih.gov/28551683