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RESEARCH PRODUCT
An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in Coronavirus Disease 2019
Alessandra SacchiFabrizio BenedettiMarkus MaeurerFabrizio PalmieriFranco LocatelliNazario BevilacquaMaria Rosaria CapobianchiEleonora CiminiEleonora TartagliaChiara AgratiEmanuele NicastriNicola PetrosilloRita CasettiGianpiero D'offiziAlimuddin ZumlaAlimuddin ZumlaGiuseppe IppolitoAndrea AntinoriStefania NotariVeronica BordoniLuisa MarchioniGermana GrassiMaria Letizia Giancolasubject
0301 basic medicineMicrobiology (medical)medicine.medical_treatmentMDSCInflammationchemical and pharmacologic phenomenaNK cellsProinflammatory cytokineNatural killer cell03 medical and health sciences0302 clinical medicineImmune systemmedicineCytotoxic T cellcytotoxic cellcytotoxic cellsbiologybusiness.industryCOVID-19COVID-19; cytotoxic cells; inflammation; MDSC; NK cells030104 developmental biologymedicine.anatomical_structureCytokineInfectious DiseasesPerforinSettore MED/38 - PEDIATRIA GENERALE E SPECIALISTICAinflammation030220 oncology & carcinogenesisImmunologybiology.proteinMyeloid-derived Suppressor Cellmedicine.symptombusinessdescription
Abstract Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-05-14 | Clinical Infectious Diseases |