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RESEARCH PRODUCT
Methods for Evaluating the Interaction Between Social Stress and Environmental Enrichment in Animal Models of Nicotine Addiction
Rosa RedolatSantiago MonleónConcepción Vinader-caerolsPatricia Mesa-gresaAránzazu Duquesubject
Social stressEnvironmental enrichmentAddictionmedia_common.quotation_subjectmedicine.diseaseNicotine Addiction030227 psychiatryNicotineSubstance abuse03 medical and health sciences0302 clinical medicinePsychosocial stressmedicineChronic stressPsychology030217 neurology & neurosurgeryClinical psychologymedia_commonmedicine.drugdescription
The environmental enrichment (EE) paradigm has been evaluated as a means of counteracting some of the consequences of chronic stress in rodents as well as a model of protective environment against drug abuse development. In the present chapter, our main aim is to describe the models of EE and chronic social stress and how they can be applied jointly in order to evaluate the effects of early psychosocial stress in animals exposed of different environments (enriched environment or standard environment). Furthermore, both paradigms could be applied in animal models of nicotine addiction, so the guidelines for the application of a chronic oral nicotine treatment in mice will be described. The heterogeneity of the procedures carried out in different laboratories makes it interesting to specify their characteristics in order to obtain replicable and valid animal models.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-01 |