6533b85afe1ef96bd12b8cd2
RESEARCH PRODUCT
Diagnosis of human immunodeficiency virus (HIV) infection: multicenter evaluation of a newly developed anti-HIV 1 and 2 enzyme immunoassay.
Peter PiotG VercauterenF AvillezF D'agostinoW MelchiorU. MichlM H LourencoH BayerG CambieG. Hesssubject
Microbiology (medical)MaleHIV AntigensHIV InfectionsHIV AntibodiesGp41Sensitivity and SpecificityVirusDiagnosis DifferentialImmunoenzyme TechniquesAcquired immunodeficiency syndrome (AIDS)PregnancyImmunopathologyHIV SeropositivityMedicineHumansSidamedicine.diagnostic_testbiologybusiness.industryvirus diseasesmedicine.diseasebiology.organism_classificationVirologyRecombinant ProteinsHIV AntigensEvaluation Studies as TopicImmunoassayImmunologyHIV-2HIV-1FemaleViral diseasebusinessResearch Articledescription
A new anti-human immunodeficiency virus type 1 and 2 (anti-HIV 1 and 2) test is described. It uses recombinant p24 and peptides covering gp32, gp41, and gp120 to identify HIV-1 and HIV-2 infections. This test has been shown to be specific (99.5%) and sensitive (99.8%). In this respect, the assay was equal or superior to anti-HIV 1 and 2 tests run as references. The test was able to discriminate sera from patients with HIV infections from those from uninfected individuals with excellence; it also exerted high intra- and interassay precisions. The "modular" concept of the test allows the use of single components (gp32 or gp41) to separate between HIV-2 and HIV-1 infections, respectively.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1994-02-01 | Journal of clinical microbiology |