6533b85afe1ef96bd12b8e32
RESEARCH PRODUCT
The mechanism of epithelial shedding after ischemic damage to the small intestinal mucosa
P. HöhnR. WagnerHelmut E. Gabbertsubject
MalePathologymedicine.medical_specialtyCellIschemiaBiologyBasement MembranePathology and Forensic Medicinelaw.inventionIntestinal mucosaIschemialawIntestine SmallmedicineAnimalsRegenerationIntestinal MucosaBasement membraneAnatomymedicine.diseaseEpitheliumRatsMicroscopy Electronmedicine.anatomical_structureCytoplasmElectron microscopeLigationdescription
The intestinal mucosa of the rat was examined by light and electron microscopy 15, 30, 60 and 120 min after complete ligation of the vessel arcades of the proximal jejunum. The characteristic sign of ischemic damage to the small intestinal mucosa and the reason for epithelial shedding is the appearance of membrane enclosed cytoplasmic blebs which arise at the cell base of the enterocytes and detach the epithelium from the basement membrane. This process begins at the tip of the villi before the enterocytes display signs of irreversible damage and progress to the base of the villi with continuation of the ischemia.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1979-12-01 | Virchows Archiv B Cell Pathology |