6533b85afe1ef96bd12b95c1

RESEARCH PRODUCT

A radiomics evaluation of 2D and 3D MRI texture features to classify brain metastases from lung cancer and melanoma

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[EN] Brain metastases are occasionally detected before diagnosing their primary site of origin. In these cases, simple visual examination of medical images of the metastases is not enough to identify the primary cancer, so an extensive evaluation is needed. To avoid this procedure, a radiomics approach on magnetic resonance (MR) images of the metastatic lesions is proposed to classify two of the most frequent origins (lung cancer and melanoma). In this study, 50 T1-weighted MR images of brain metastases from 30 patients were analyzed: 27 of lung cancer and 23 of melanoma origin. A total of 43 statistical texture features were extracted from the segmented lesions in 2D and 3D. Five predictive models were evaluated using a nested cross-validation scheme. The best classification results were achieved using 3D texture features for all the models, obtaining an average AUC > 0.9 in all cases and an AUC = 0.947 +/- 0.067 when using the best model (naive Bayes).