6533b85afe1ef96bd12b9f0b

RESEARCH PRODUCT

Oxygen Radical Scavengers

Uwe MehlhornJack A. T. C. Parker

subject

chemistry.chemical_classificationmedicine.medical_specialtyReactive oxygen speciesMyocardial ischemiabusiness.industryRadicalIschemiaIntracellular reactive oxygen speciesmedicine.diseasechemistry.chemical_compoundchemistryMitochondrial permeability transition poreInternal medicinemedicineCardiologyMyocardial cellcardiovascular diseasesXanthine oxidasebusiness

description

The myocardium can tolerate only relatively short periods of total myocardial ischemia without myocardial cell death. Following short ischemic periods, ischemic damage is reversible by reperfusion. However, with increasing duration and severity of ischemia, the damage inflicted to cardiomyocytes following reperfusion becomes irreversible. The combined pathologic events in the myocardium that follow a critical period of ischemia and leading to either reversible or irreversible damage to both cardiomyocytes and cardiac microvasculature is known as ischemia-reperfusion injury (Goldhaber and Weiss 1992).

yearjournalcountryeditionlanguage
2010-09-08
https://doi.org/10.1007/978-3-211-85548-5_11