6533b85afe1ef96bd12ba04f

RESEARCH PRODUCT

Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles

Holger UlbrichGerd DannhardtMichael Scholz

subject

AzolesModels MolecularMagnetic Resonance SpectroscopyAntioxidantStereochemistryRadicalmedicine.medical_treatmentInflammationPharmacologychemistry.chemical_compoundDrug DiscoverymedicineCyclooxygenase InhibitorsLipoxygenase InhibitorsSelenium CompoundsPharmacologychemistry.chemical_classificationReactive oxygen speciesbiologyChemistryEbselenOrganic ChemistryFree Radical ScavengersGeneral MedicineEnzyme inhibitorArachidonate 5-lipoxygenasebiology.proteinHydroxyl radicalmedicine.symptom

description

The aim of this study was to investigate 4,5-diaryl isoselenazoles as multiple target non-steroidal anti-inflammatory drugs (MTNSAIDs) which can intervene into the inflammatory processes via different mechanisms of action creating a new class of compounds. Here we describe the synthesis of COX/LOX inhibitors which additionally reduce the level of reactive oxygen species, such as hydroxyl radicals which are well known for supporting inflammation processes in Parkinson's disease, Alzheimer's disease and rheumatoid arthritis.

yearjournalcountryeditionlanguage
2007-03-12European Journal of Medicinal Chemistry
https://doi.org/10.1016/j.ejmech.2007.09.007