6533b85bfe1ef96bd12ba194
RESEARCH PRODUCT
Studies on the subcellular pathophysiology of sublethal chronic cell injury.
Benjamin F. TrumpAntti U. ArstilaPirkko Hirsimäkisubject
AdultMaleTime FactorsTranscription GeneticSurface PropertiesCellsCellGuinea PigsBronchiBiologyMicrofilamentMicrotubulesPathology and Forensic MedicineMuscle hypertrophyCell Physiological PhenomenaCell membraneMiceMicrotubuleTranscription (biology)medicineAnimalsHumansCerebral CortexMacrophagesMusclesCell MembraneBiological TransportGeneral MedicineHypertrophyMiddle AgedPathophysiologyCell biologyMicroscopy Electronmedicine.anatomical_structureLiverUltrastructureRabbitsLysosomesCell Divisiondescription
Summary This paper summarizes some of the important subcellular events occurring after chronic sublethal cell injury. Chronic cell injury is defined as the result of injurious stimuli which permit cell survival though in altered steady states for protracted periods of time. The importance of ultrastructural and biochemical studies of these phenomena is emphasized. Among the phenomena discussed are alterations in lysosomes, cellular hypertrophy, fatty metamorphosis, alterations in microfilaments and microtubules, alterations in mechanisms of transcription and replication, disturbances in the cell surface and transport across the cell membrane, and alterations in intracellular transport.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1974-09-01 | Beitrage zur Pathologie |