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RESEARCH PRODUCT

Effect of pistachio on brachial artery diameter and flow-mediated dilatation: A systematic review and meta-analysis of randomized, controlled-feeding clinical studies

Maddalena VeronesiGiuseppe DerosaManfredi RizzoFederica FogacciClaudio BorghiArrigo F G Cicero

subject

Isi web of sciencemedicine.medical_specialtyBrachial Artery030309 nutrition & dieteticsMEDLINEIndustrial and Manufacturing Engineeringbrachial artery diameter03 medical and health sciences0404 agricultural biotechnologyInternal medicinemedicine.arteryflow mediated dilatationmedicineHumansBrachial arteryPistachioRandomized Controlled Trials as Topic0303 health sciencesbusiness.industry04 agricultural and veterinary sciencesGeneral Medicine040401 food scienceDietendothelial reactivityStudy CharacteristicsSurgeryVasodilationmeta-analysisClinical trialSystematic reviewMeta-analysisPistaciaEndothelium VascularbusinessPublication BiasBlood Flow VelocityFood Science

description

Background: Results of previous clinical trials evaluating the effect of pistachio supplementation on endothelial reactivity (ER) are controversial. Aims: We aimed to assess the impact of pistachio on ER through systematic review of literature and meta-analysis of available randomized, controlled-feeding clinical studies (RCTs). Methods: The literature search included SCOPUS, PubMed-Medline, ISI Web of Science and Google Scholar databases up to 1st August 2017 to identify RCTs investigating the impact of pistachio on ER. Two independent reviewers extracted data on study characteristics, methods and outcomes. Overall, the impact of pistachio on ER was reported in 4 trials. Results: The meta-analysis did not suggest a significant change in brachial artery flow-mediated dilatation (FMD) (WMD: +0.28%; 95%CI: −0.58, 1.13; p = 0.525) while brachial artery diameter (BAD) improved (WMD: +0.04%; 95%CI: 0.03, 0.06; p<0.001) following pistachios consumption. Conclusion: The present meta-analysis suggests a significant effect of pistachios on ER, affecting BAD but not FMD

yearjournalcountryeditionlanguage
2017-10-17Critical Reviews in Food Science and Nutrition
https://doi.org/10.1080/10408398.2017.1368007