6533b85bfe1ef96bd12ba920
RESEARCH PRODUCT
Animal models: Murine cytomegalovirus
Matthias J. ReddehaseJürgen PodlechNatascha K. A. GrzimekRafaela Holtappelssubject
biologyvirusesViral pathogenesisvirus diseasesCytomegalovirusmedicine.disease_causebiology.organism_classificationVirologyHerpesviridaeVirusImmune systemViral replicationBetaherpesvirinaeImmunologymedicineCytotoxic T celldescription
Publisher Summary This chapter focuses on murine cytomegalovirus (CMV) animal models. Multiple-organ cytomegalovirus disease, interstitial pneumonia in particular, is a major concern in the therapy of hematopoietic malignancies by hematoablative treatment and bone marrow transplantation (BMT). Human CMV (hCMV) is the prototype member of the subfamily, Betaherpesvirinae, of the virus family, Herpesviridae . Its genome is a linear, double-stranded DNA with a coding capacity of ca. 165 open reading frames. During an aeon of co-evolution, CMVs have adapted themselves to their respective hosts; therefore, CMV biology is most reliably studied in a natural virus-host combination. Even though hCMV and murine CMV (mCMV) differ molecularly, basic principles in viral pathogenesis are the same. The murine model has been paradigmatic for many aspects of the immune control of CMVs. Specifically, the importance of CD8 T cells and of the viral immediate-early protein in the protective immune response, as well as immune evasion strategies of CMVs, have first been documented in this model. The chapter discusses bone marrow transplantation and infection and explains the detection of virus replication in organs.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-01-01 |