6533b85bfe1ef96bd12babdb

RESEARCH PRODUCT

Hippocampal subfields predict positive symptoms in schizophrenia : First evidence from brain morphometry

Simone KühnFrancesco MussoJuergen GallinatArian MobascherArian MobascherGeorg WintererGeorg WintererTracy Warbrick

subject

AdultMalegenetic structureshippocampusFreeSurferHippocampusHippocampal formationCA1Cellular and Molecular NeurosciencemedicineImage Processing Computer-AssistedHumansddc:610Biological PsychiatryvolumetryPsychiatric Status Rating Scalesmedicine.diagnostic_testBrain morphometryMagnetic resonance imagingOrgan Sizemedicine.diseaseMagnetic Resonance ImagingJschizophreniaPsychiatry and Mental healthnervous systemCA2/3SchizophreniaPsychiatric status rating scalesOriginal ArticleFemaleNegative correlationPsychologyNeuroscienceSymptom score

description

Alterations of hippocampal anatomy have been reported consistently in schizophrenia. Within the present study, we used FreeSurfer to determine hippocampal subfield volumes in 21 schizophrenic patients. A negative correlation between PANSS-positive symptom score and bilateral hippocampal subfield CA2/3 as well as CA1 volume was found on high-resolution magnetic resonance images. Our observation opens the gate for advanced investigation of the commonly reported hippocampal abnormalities in schizophrenia in terms of specific subfields.

yearjournalcountryeditionlanguage
2012-06-01
10.1038/tp.2012.51https://hdl.handle.net/11858/00-001M-0000-002B-A3D1-311858/00-001M-0000-0024-EF16-1