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RESEARCH PRODUCT
Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes
Milagros RochaCelia BañulsAntonio Hernández-mijaresOlalla Rubio-pucholÁNgeles ÁLvarezSamuel OrdenSusana Rovira-llopisVictor M. Victorsubject
medicine.medical_specialtyMedicine (miscellaneous)Type 2 diabetesmedicine.disease_causechemistry.chemical_compoundInternal medicinemedicineTX341-641InositolVCAM-1Endothelial dysfunctionDiminutionInflammationICAM-1Nutrition and DieteticsNutrition. Foods and food supplyType 2 diabetesEndothelial functionmedicine.diseaseEndocrinologyPostprandialchemistryOxidative stressOxidative stressInositolFood Sciencedescription
The anti-diabetic properties of an inositol-enriched beverage (IEB) on the endothelial function and redox status in diabetic subjects were assessed. This was a 12-week, double-blind randomized controlled trial employing thirty-eight diabetic subjects that were divided into two intervention groups: one receiving an IEB and the other a sucrose-enriched beverage. Subjects consuming IEB exhibited a significant decrease in triacylglycerol (8.82%) and HbA1c (4.53%) levels. Continuous glucose monitoring revealed a significant net reduction of 2.51 and 7.11% during postprandial and overnight fasting periods after consumption of IEB, respectively. Moreover, IEB improved endothelial function by reducing P-selectin levels and leucocyte-endothelium interactions, as there was an increase in rolling velocity and a reduction in polymorphonuclear leucocyte adhesion and induced a significant diminution in the generation of ROS. The present results show that IEB supplementation induces a significant improvement in glycaemic control in diabetic subjects by improving endothelial function and intracellular redox status. (C) 2015 Elsevier Ltd. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-10-01 |