6533b85bfe1ef96bd12bb2a0

RESEARCH PRODUCT

Fluorescence spectroscopy for estimation of anticancer drug sonodestruction in vitro

C. W. LoAlexey LihachevSaulius ŠAtkauskasInesa FerulovaJanis SpigulisWen-shiang ChenMindaugas TamosiunasDainis Jakovels

subject

Materials sciencebusiness.industryUltrasoundUltrasound exposurerespiratory systemPharmacologyBleomycinFluorescenceAnticancer drugIn vitroFluorescence spectroscopyrespiratory tract diseasescarbohydrates (lipids)chemistry.chemical_compoundNuclear magnetic resonancechemistrybusinessSonoporation

description

The effect of ultrasound exposure on bleomycin fluorescence and pharmacological properties is studied. Bleomycin was treated by ultrasound for 7 min. Bleomycin fluorescence was measured during ultrasound exposure by means of fiber-optic spectrometry. Cell colony test was used to evaluate blemycin cytotoxity before and after ultrasound exposure.

https://doi.org/10.1117/12.2044658