6533b85bfe1ef96bd12bb58e

RESEARCH PRODUCT

Inhibition of pro-inflammatory enzymes by inuviscolide, a sesquiterpene lactone from Inula viscosa

Victoriano HernándezJosé-luis RíosMaría Del Carmen RecioRosa-maría GinerSalvador Máñez

subject

DermatitisBiologyPharmacognosyPharmacologySesquiterpene lactoneSesquiterpeneLactonesMicechemistry.chemical_compoundDrug DiscoveryLeukocytesAnimalsHumansEnzyme InhibitorsPharmacologychemistry.chemical_classificationPancreatic Elastaseintegumentary systemPlant ExtractsAnti-Inflammatory Agents Non-SteroidalElastaseBiological activityGeneral MedicineEnzymechemistryBiochemistrybiology.proteinTetradecanoylphorbol AcetateInulaCyclooxygenaseSesquiterpenesLactonePhytotherapy

description

Abstract This work concerns the pharmacological activity of inuviscolide, a sesquiterpenoid from Inula viscosa. It exerts inhibitory effects on elastase, cyclooxygenase 1 and secretory phospholipase A2. Furthermore, it reduces the skin leukocyte infiltration in a murine model of dermatitis induced by repeated application of 12-O-tetradecanoylphorbol 13-acetate.

yearjournalcountryeditionlanguage
2006-02-08Fitoterapia
https://doi.org/10.1016/j.fitote.2007.03.005