6533b85bfe1ef96bd12bbd5d

RESEARCH PRODUCT

351 Substantial lymph-vascular space invasion (LVSI) as predictor of distant relapse and poor prognosis in low-risk early stage endometrial cancer

Giuseppe VizzielliGiovanni ScambiaGian Franco ZannoniLucia TortorellaGiorgia DinoiE La FeraSerena CappuccioF FanfaniS RestainoAlessandro GioèVito ChianteraGiuseppe Angelico

subject

Oncologymedicine.medical_specialtyPoor prognosisbusiness.industryEndometrial cancerDistant relapseCancermedicine.diseaseVascular spaceInternal medicinemedicineLymphStage (cooking)Risk factorbusiness

description

Objective To evaluate the prognostic role of LVSI, evaluated in a semi-quantitative fashion on prognosis of early stage, low risk endometrial cancer (EC). Methods We enrolled patients who underwent surgery for EC between 2003 and 2018 in two referral cancer center. All patients had endometrioid EC, G1-G2, with myometrial invasion Results Among 524 patients, any positive LVSI was found in 57 patients (10.9%) with 6.7% (n=35) focal LVSI and 4.2% (n=22) substantial LVSI. Substantial LVSI was associated to higher rate of G2 (p Conclusions Substantial LVSI represents the strongest independent risk factor for decreased survival and distant relapse, indicating a role for potential hematogenous dissemination.

yearjournalcountryeditionlanguage
2020-11-01Poster
https://doi.org/10.1136/ijgc-2020-igcs.302