6533b85cfe1ef96bd12bc004

RESEARCH PRODUCT

High frequency repetitive transcranial magnetic stimulation (rTMS) reduces EEG-hypofrontality in patients with schizophrenia.

Mareke HabakuckDaniel KampArian MobascherWolfgang WölwerMarcus W. AgelinkJürgen BrinkmeyerJoachim Cordes

subject

AdultMalemedicine.medical_treatmentPrefrontal CortexHypofrontalityElectroencephalography03 medical and health sciences0302 clinical medicinemedicineHumansIn patientPrefrontal cortexBiological PsychiatryFacial affectmedicine.diagnostic_testBrainElectroencephalographymedicine.diseaseTranscranial Magnetic Stimulation030227 psychiatryTranscranial magnetic stimulationPsychiatry and Mental healthElectrophysiologyDelta RhythmSchizophreniaSchizophreniaFemaleSchizophrenic PsychologyPsychologyNeuroscienceFacial Recognition030217 neurology & neurosurgery

description

The reduced metabolic activity in the prefrontal brain lobes, so-called hypofrontality, is associated with increased electrophysiological delta-band activity. Schizophrenia inpatients (N=35) received sham-controlled 10Hz rTMS over the left dorsolateral prefrontal cortex in a randomised design. After treatment, the resting electroencephalography revealed a significant decrease in the delta-band activity, which originated in the right prefrontal cortex and correlated with improvements in facial affect recognition.

yearjournalcountryeditionlanguage
2015-04-16Psychiatry research
10.1016/j.psychres.2016.01.007https://pubmed.ncbi.nlm.nih.gov/26778629