Identification of acute myocardial infarction in elderly patients using optimized highly sensitive troponin I thresholds

6533b85cfe1ef96bd12bc066

RESEARCH PRODUCT

Identification of acute myocardial infarction in elderly patients using optimized highly sensitive troponin I thresholds

Thomas Münzel Karl J. Lackner Philipp S. Wild Stergios Tzikas Tanja Zeller Till Keller Christoph Bickel Fachrie Sar Marco Tubaro Beatrice Von Jeinsen Stephan Baldus Tommaso Gori Christian W. Hamm Andreas M. Zeiher Alexander F. Schmidt Christoph Liebetrau Lars Palapies Blankenberg Stefan

subject

Adult Male medicine.medical_specialty Cardiac troponin Health Toxicology and Mutagenesis health care facilities manpower and services Clinical Biochemistry Myocardial Infarction Hyperlipidemias 030204 cardiovascular system & hematology Biochemistry Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Troponin I medicine Humans Myocardial infarction Prospective Studies cardiovascular diseases health care economics and organizations Aged Aged 80 and over biology business.industry Smoking Troponin I Middle Aged medicine.disease Troponin humanities Highly sensitive 030220 oncology & carcinogenesis Hypertension Cardiology biology.protein Female business Biomarkers

description

Purpose: Established diagnostic thresholds for high-sensitivity cardiac troponins (hs-cTn) might not apply for elderly patients as they are elevated irrespective of the presence of an acute myocardial infarction (AMI). Aim of the present study was to investigate hs-cTnI in elderly patients with suspected AMI and to calculate optimized diagnostic cutoffs. Material and methods: Data from a prospective multi-centre study and from a second independent prospective single-centre cohort study were analysed. A number of 2903 patients were eligible for further analysis. Patients > 70 years were classified as elderly. hs-cTnI was measured upon admission. Results: Around 34.7% of 2903 patients were classified as elderly. Around 22.5% of elderly patients were finally diagnosed with AMI. Elderly patients had higher hs-cTnI levels at admission irrespective of the final diagnosis (p Conclusions: hs-cTnI levels have a lower specificity for detecting AMI in elderly patients. This lower specificity can be improved by using hs-cTnI thresholds optimized for elderly patients.

year	journal	country	edition	language
2019-01-01

https://dx.doi.org/10.6084/m9.figshare.9879281