0000000000413878

AUTHOR

Beatrice Von Jeinsen

showing 5 related works from this author

Troponin I Assay for Identification of a Significant Coronary Stenosis in Patients with Suspected Acute Myocardial Infarction and Wide QRS Complex

2016

Background Common ECG criteria such as ST-segment changes are of limited value in patients with suspected acute myocardial infarction (AMI) and bundle branch block or wide QRS complex. A large proportion of these patients do not suffer from an AMI, whereas those with ST-elevation myocardial infarction (STEMI) equivalent AMI benefit from an aggressive treatment. Aim of the present study was to evaluate the diagnostic information of cardiac troponin I (cTnI) in hemodynamically stable patients with wide QRS complex and suspected AMI. Methods In 417 out of 1818 patients presenting consecutively between 01/2007 and 12/2008 in a prospective multicenter observational study with suspected AMI a pro…

MaleCardiovascular ProceduresMyocardial Infarctionlcsh:MedicineCoronary Artery Disease030204 cardiovascular system & hematologyPathology and Laboratory MedicineBiochemistryVascular MedicineCoronary artery diseaseElectrocardiographyPatient Admission0302 clinical medicineTroponin IMedicine and Health SciencesMedicine030212 general & internal medicineMyocardial infarctionlcsh:ScienceStenosisMultidisciplinarymedicine.diagnostic_testbiologyMiddle AgedTroponinBioassays and Physiological Analysiscardiovascular systemCardiologyFemaleAlgorithmsResearch Articlemedicine.medical_specialtyCardiologySurgical and Invasive Medical ProceduresResearch and Analysis MethodsSensitivity and Specificity03 medical and health sciencesSigns and SymptomsDiagnostic MedicineInternal medicineHumansddc:610cardiovascular diseasesAgedCoronary RevascularizationBundle branch blockReceiver operating characteristicbusiness.industryRevascularizationElectrophysiological TechniquesAngioplastyTroponin Ilcsh:RCoronary StenosisBiology and Life SciencesProteinsmedicine.diseaseTroponinCytoskeletal Proteinsbiology.proteinMyocardial infarction complicationslcsh:QCardiac ElectrophysiologybusinessCoronary AngioplastyElectrocardiographyBiomarkersPLOS ONE
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Estimation of Values below the Limit of Detection of a Contemporary Sensitive Troponin I Assay Improves Diagnosis of Acute Myocardial Infarction

2015

Abstract BACKGROUND The limit of detection (LoD) is the minimal amount of a substance that can be consistently detected. In the diagnosis of acute myocardial infarction (AMI) many patients present with troponin concentrations below the LoD of contemporary sensitive cardiac troponin I (cs-cTnI) assays. These censored values below the LoD influence the diagnostic performance of these assays compared to highly sensitive cTnI (hs-cTnI) assays. Therefore we assessed the impact of a new approach for interpolation of the left-censored data of a cs-cTnI assay in the evaluation of patients with suspected AMI. METHODS Our posthoc analysis used a real world cohort of 1818 patients with suspected MI. D…

Malemedicine.medical_specialtyClinical BiochemistryMyocardial Infarctionmacromolecular substancesCohort StudiesLimit of DetectionInternal medicineTroponin ImedicineHumanscardiovascular diseasesMyocardial infarctionAgedAged 80 and overDetection limitbiologybusiness.industryTroponin IBiochemistry (medical)Area under the curveMiddle AgedPrognosismedicine.diseaseTroponinCensoring (statistics)SurgeryROC CurveArea Under CurveAcute DiseaseCohortcardiovascular systemCardiologybiology.proteinRegression AnalysisFemaleMyocardial infarction diagnosisbusinessClinical Chemistry
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Cardiac Troponins for the Diagnosis of Acute Myocardial Infarction in Chronic Kidney Disease

2018

Background Patients with chronic kidney disease ( CKD ) are at high risk of myocardial infarction. Cardiac troponins are the biomarkers of choice for the diagnosis of acute myocardial infarction ( AMI ) without ST ‐segment elevation ( NSTE ). In patients with CKD , troponin levels are often chronically elevated, which reduces their diagnostic utility when NSTE ‐ AMI is suspected. The aim of this study was to derive a diagnostic algorithm for serial troponin measurements in patients with CKD and suspected NSTE ‐ AMI . Methods and Results Two cohorts, 1494 patients from a prospective cohort study with high‐sensitivity troponin I (hs‐ cTnI ) measurements and 7059 cases from a clinical registr…

Malemedicine.medical_specialtyCardiac troponinNephrology and KidneyMyocardial InfarctionDiagnostic Testingmacromolecular substances030204 cardiovascular system & hematologynon‐ST‐segment elevation acute coronary syndromeurologic and male genital diseases03 medical and health sciences0302 clinical medicineTroponin TInternal medicinecohort studymedicineHumansProspective Studiescardiovascular diseasesddc:610030212 general & internal medicineMyocardial infarctionRenal Insufficiency ChronicOriginal ResearchAgedKidney in Cardiovascular Diseasebusiness.industryTroponin IMiddle AgedPrognosismedicine.diseasefemale genital diseases and pregnancy complicationsdecision aidsCardiologybiomarkerBiomarker (medicine)FemaleCardiology and Cardiovascular MedicinebusinessAcute Coronary Syndromeschronic kidney diseaseBiomarkersFollow-Up StudiesGlomerular Filtration RateKidney diseaseCohort studyJournal of the American Heart Association
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Identification of acute myocardial infarction in elderly patients using optimized highly sensitive troponin I thresholds

2019

Purpose: Established diagnostic thresholds for high-sensitivity cardiac troponins (hs-cTn) might not apply for elderly patients as they are elevated irrespective of the presence of an acute myocardial infarction (AMI). Aim of the present study was to investigate hs-cTnI in elderly patients with suspected AMI and to calculate optimized diagnostic cutoffs. Material and methods: Data from a prospective multi-centre study and from a second independent prospective single-centre cohort study were analysed. A number of 2903 patients were eligible for further analysis. Patients > 70 years were classified as elderly. hs-cTnI was measured upon admission. Results: Around 34.7% of 2903 patients were…

AdultMalemedicine.medical_specialtyCardiac troponinHealth Toxicology and Mutagenesishealth care facilities manpower and servicesClinical BiochemistryMyocardial InfarctionHyperlipidemias030204 cardiovascular system & hematologyBiochemistrySensitivity and Specificity03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicineTroponin ImedicineHumansMyocardial infarctionProspective Studiescardiovascular diseaseshealth care economics and organizationsAgedAged 80 and overbiologybusiness.industrySmokingTroponin IMiddle Agedmedicine.diseaseTroponinhumanitiesHighly sensitive030220 oncology & carcinogenesisHypertensionCardiologybiology.proteinFemalebusinessBiomarkers
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Urinary neutrophil gelatinase-associated lipocalin and cystatin C compared to the estimated glomerular filtration rate to predict risk in patients wi…

2016

Abstract Introduction Impaired renal function, reflected by estimated glomerular filtration rate (eGFR) or cystatin C, is a strong risk predictor in the presence of acute myocardial infarction (AMI). Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is an early marker of acute kidney injury. uNGAL might also be a good predictor of outcome in patients with cardiovascular disease. Aim of the present study was to evaluate the prognostic value of uNGAL compared to eGFR and cystatin C in patients with suspected AMI. Methods 1818 patients were enrolled with suspected AMI. Follow-up information on the combined endpoint of death or non-fatal myocardial infarction was obtained 6months after…

Malemedicine.medical_specialtyUrinary systemMyocardial InfarctionRenal function030204 cardiovascular system & hematologyurologic and male genital diseasesCohort Studies03 medical and health sciences0302 clinical medicineLipocalin-2Predictive Value of TestsRisk FactorsInternal medicinemedicineClinical endpointHumans030212 general & internal medicineMyocardial infarctionCystatin CAgedAged 80 and overFramingham Risk Scorebiologybusiness.industryAcute kidney injuryMiddle Agedmedicine.diseaseCystatin Cbiology.proteinCardiologyFemaleCystatinCardiology and Cardiovascular MedicinebusinessBiomarkersFollow-Up StudiesGlomerular Filtration RateInternational journal of cardiology
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