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RESEARCH PRODUCT
Serum leptin is associated with serum uric acid concentrations in humans.
A. PfütznerAchim PetersBernd Fruehwald-schultesJürgen BeyerWerner Kernsubject
LeptinMalemedicine.medical_specialtyEndocrinology Diabetes and MetabolismLipoproteinsBody Mass Indexchemistry.chemical_compoundEndocrinologyWaist–hip ratioSex FactorsInternal medicinemedicineHumansHyperuricemiaObesityTriglyceridesAnalysis of VarianceTriglycerideChemistryLeptinnutritional and metabolic diseasesProteinsSyndromeMiddle Agedmedicine.diseaseObesityUric AcidEndocrinologyCross-Sectional StudiesAdipose TissueDiabetes Mellitus Type 2Case-Control StudiesHypertensionLinear ModelsUric acidBody ConstitutionFemaleMetabolic syndromeBody mass indexdescription
This cross-sectional study aimed to evaluate the relationship between leptin and the cluster of abnormalities often referred to as the metabolic syndrome. The serum leptin concentration, body mass index (BMI), percent body fat, total fat mass (FM), waist and hip circumference, waist to hip ratio (WHR), prevalence of hypertension, and triglyceride (TG), lipoprotein, and uric acid concentration were determined in 86 type 2 diabetic (n = 59) and healthy (n = 27) subjects. Multiple regression analyses showed that the estimates of total body obesity (BMI, percent body fat, and total FM), sex, and serum uric acid concentration are independently associated with the serum leptin concentration. The finding of a positive correlation between serum leptin and uric acid levels suggests that leptin could be a pathogenic factor responsible for hyperuricemia in obesity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-06-01 | Metabolism: clinical and experimental |