6533b85cfe1ef96bd12bca81
RESEARCH PRODUCT
Crystal structure of hydrocortisone 17-butyrate
Wei ShenYu ZhuHai-li Wangsubject
inorganic chemicalscrystal structureCrystallographyHydrogen bondCyclohexane conformationeducationGeneral ChemistryButyrateCrystal structureCondensed Matter PhysicsBioinformaticsData ReportshumanitiesCrystalchemistry.chemical_compoundCrystallographychemistryQD901-999Atomhydrogen bondshydrocortisone derivativehydrocortisone derivativeGeneral Materials Sciencepharmacological activityMethyl groupdescription
In the title compound, C25H36O6, the two central cyclohexane rings exhibit a chair conformation. The terminal cyclohexene and cyclopentane rings are in half-chair and envelope conformations (with the C atom bearing the methyl substituent as the flap), respectively. The methyl group of the butyrate chain is disordered over two orientations, with a refined occupancy ratio of 0.742 (6):0.258 (6). Intramolecular O—H...O and C—H...O hydrogen bonds are observed. In the crystal, molecules are linked by O—H...O hydrogen bonds into chains running parallel to theaaxis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-12-01 | Acta Crystallographica Section E |