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RESEARCH PRODUCT
Association between reduced bronchodilatory effect of deep inspiration and loss of alveolar attachments.
Antonio M. VignolaAlkis TogiasAndreina BrunoRoberto MarcheseScichilone NicolaVincenzo Belliasubject
Pulmonary and Respiratory MedicineMalemedicine.medical_specialtyPathologyStatistics as TopicBronchial provocation testsCOPD lung inflationBronchi030204 cardiovascular system & hematologySettore MED/10 - Malattie Dell'Apparato RespiratorioBronchial Provocation Tests03 medical and health sciencesPulmonary Disease Chronic Obstructive0302 clinical medicineInternal medicinemedicineHumansLung volumesMethacholine ChlorideAgedlcsh:RC705-779COPDbusiness.industryResearchAirway smooth musclelcsh:Diseases of the respiratory systemrespiratory systemmedicine.diseaserespiratory tract diseasesPulmonary Alveoli030228 respiratory systemMethacholine chlorideInhalationAirway wallCardiologyMethacholineFemalebusinessmedicine.drugdescription
Abstract Background We have previously shown that the bronchodilatory effect of deep inspiration is attenuated in individuals with COPD. This study was designed to investigate whether the impairment in this effect is associated with loss of alveolar attachments. Methods We measured deep inspiration (DI)-induced bronchodilation in 15 individuals with and without COPD (67 ± 2.2 yrs of age, mean ± SEM) undergoing lobar resection for peripheral pulmonary nodule. Prior to surgery, we measured TLCO and determined the bronchodilatory effect of deep inspiration after constricting the airways with methacholine. The number of destroyed alveolar attachments, as well as airway wall area and airway smooth muscle area, were determined in tumor-free, peripheral lung tissue. Results The bronchodilatory effect of deep inspiration correlated inversely with the % destroyed attachments (r = -0.51, p = 0.05) and directly with the airway smooth muscle area (r = 0.59, p = 0.03), but not with the total wall area (r = 0.39, p = 0.15). Conclusion We postulate that attenuation of airway stretch due to loss of alveolar attachments contributes to the loss of the bronchodilatory effect of lung inflation in COPD.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-03-07 | Respiratory research |