6533b85cfe1ef96bd12bd617
RESEARCH PRODUCT
Induction of Neuronal Differentiation in Neurosphere Stem Cells by Ellagic Acid Derivatives
Anne Claire Mitaine-offerBonaventure T. NgadjuiBang LuuJoseph NgoupayoTuribio Kuiate TabopdaMarie-aleth Lacaille-duboisJia Wei Liusubject
Nervous systemPlant ScienceChemical FractionationBiologyPharmacologyMicechemistry.chemical_compoundEllagic AcidEpidermal growth factorNeurosphereDrug DiscoveryBotanymedicineAnimalsCytotoxic T cellCells CulturedNeuronsPharmacologyStem CellsCell DifferentiationGeneral MedicineIn vitroNeural stem cellmedicine.anatomical_structureComplementary and alternative medicinechemistryTerminaliaStem cellEllagic aciddescription
A bioassay-guided fractionation of methanol extracts of stem barks, combined with screening based on Epidermal Growth Factor (EGF)-responsive neural stem cells (erNSCs) differentiation assay, has been used. This study resulted in the isolation of 3,3′-di- O-methylellagic acid 1, 3,3′-di- O-methyl ellagic acid-4- O-β-D-xylopyranoside 2, ellagic acid 3, and arjunolic acid 4. Among them, compounds 1 and 2 exhibit potent induction of neuronal differentiation in neurosphere stem cells with no cytotoxic effect. These results indicate that compounds 1 and 2 may be useful as pharmacological agents for the treatment of neurodegenerative diseases. These compounds may account, for the use of T. superba in folk medicine for nervous system and mental disorders.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-05-30 | Natural Product Communications |