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RESEARCH PRODUCT
Contact dermatitis due to nickel allergy in patients suffering from non-celiac wheat sensitivity
Liana BoscoRosario IacobucciFrancesca CavataioAlberto D'alcamoAntonio CarroccioMaurizio SoresiGiuseppe IaconoFrancesca FayerPasquale MansuetoLaura Di StefanoFrancesco La BlascaA. AriniGirolamo Geracisubject
AdultMale0301 basic medicineNickel allergymedicine.medical_specialtyLetterSettore MED/09 - Medicina InternaNon-celiac wheat sensitivitynon-celiac wheat insensitivityNickel allergyWheat HypersensitivityArticlecutaneous symptoms03 medical and health sciences0302 clinical medicineDouble-Blind MethodNickelHypersensitivitymedicineCutaneous symptomHumansIngestionIn patientProspective StudiesProspective cohort studysystemic nickel allergy syndromeTriticumIrritable bowel syndromeNutrition and Dieteticsbusiness.industryCase-control studyPatch testnon‐celiac wheat sensitivity; nickel allergy; cutaneous symptoms; irritable bowel syndromeCutaneous symptoms; Irritable bowel syndrome; Nickel allergy; Non-celiac wheat sensitivity; Food SciencePatch Testsmedicine.diseaseintradermal testingDermatologySurgeryIrritable bowel syndromenickel allergy ; non-celiac wheat sensitivity ; irritable bowel syndrome ; cutaneous symptoms030104 developmental biologyCase-Control StudiesDermatitis Allergic ContactFemale030211 gastroenterology & hepatologybusinessContact dermatitisFood Sciencedescription
Background: Non‐celiac wheat sensitivity (NCWS) is a new clinical entity in the world of gluten‐related diseases. Nickel, the most frequent cause of contact allergy, can be found in wheat and results in systemic nickel allergy syndrome and mimics irritable bowel syndrome (IBS). Objective: To evaluate the frequency of contact dermatitis due to nickel allergy in NCWS patients diagnosed by a double‐blind placebo‐controlled(DBPC)challenge,and to identify the characteristics of NCWS patients with nickel allergy. Methods: We performed a prospective study of 60 patients (54 females, 6 males; mean age 34.1 ± 8.1 years) diagnosed with NCWS from December 2014 to November 2016; 80 age‐ and sex‐matched subjects with functional gastrointestina l symptoms served as controls. Patients reporting contact dermatitis related to nickel‐containing objects underwent nickel patch test (Clinicaltrials.gov registration number: NCT02750735).Results: Six out of sixty patients (10%) with NCWS suffered from contact dermatitis and nickel allergy and this frequency was statistically higher (p = 0.04)than observed in the control group(5%. The main clinical characteristic of NCWS patients with nickel allergy was a higher frequency of cutaneous symptoms after wheat ingestion compared to NCWS patients who did not suffer from nickel allergy (p < 0.0001. Conclusions: Contact dermatitis and nickel allergy are more frequent in NCWS patients than in subjects with functional gastrointestinal disorders;furthermore, these patients had a very high frequency of cutaneous manifestations after wheat ingestion. Nickel allergy should be evaluated in NCWS patients who have cutaneous manifestations after wheat ingestion.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-02-02 |