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RESEARCH PRODUCT

Cardiovascular disease in primary sjögren’s syndrome

Giuliana GugginoPaola CiprianiFrancesco CicciaGiovanni TrioloVasiliki LiakouliOnorina BerardicurtiPaola Di BenedettoFrancesco CarubbiRoberto GiacomelliPiero Ruscitti

subject

medicine.medical_specialtyFuture studiesEndothelial damageDiseaseType 2 diabetesComorbidity030204 cardiovascular system & hematologySjögren syndrome03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicineMedicineHumans030212 general & internal medicinePharmacologybusiness.industryRisk FactorGeneral Medicinemedicine.diseaseAtherosclerosisCardiovascular diseaseCardiovascular riskComorbiditySjögren syndromestomatognathic diseasesSettore MED/16 - ReumatologiaAtherosclerosis; Cardiovascular disease; Cardiovascular risk; Comorbidity; Endothelial damage; Sjögren syndrome; PharmacologyIncreased riskSjogren's SyndromeClose relationshipCardiovascular DiseasesAtherosclerosiSjogren sbusinessHuman

description

Background A close relationship between rheumatic diseases and cardiovascular disease (CVD) has been reported, accounting for the higher mortality and morbidity observed in these patients. In the last years, it has been clearly reported that patients affected by primary Sjogren's syndrome (pSS) experienced an increased risk of CVD. Objective This review aimed at investigating CVD, traditional cardiovascular (CV) risk factors and possible targeted therapeutic strategies in pSS patients. Method Available literature concerning CV risk factors in pSS patients has been selected and discussed. Conclusion Disease-related characteristics and traditional CV risk factors contribute to observed atherosclerotic damage in pSS patients. The pro-inflammatory mediators together with hypertension and type 2 diabetes, which are more prevalent in pSS patients, determine the increased CV burden. Future studies are needed to fully elucidate the role of possible targeted therapies.

yearjournalcountryeditionlanguage
2018-01-01
10.2174/1574887113666180315130336http://hdl.handle.net/11697/127068