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RESEARCH PRODUCT

Aerobic exercise for axial spondyloarthritis - its effects on disease activity and function as compared to standard physiotherapy: A systematic review and meta-analysis

Frank VerhoevenNicolas TordiCéline DemougeotClément PratiXavier GuillotDaniel WendlingFabienne Mougin

subject

AdultMalemedicine.medical_specialty[SDV]Life Sciences [q-bio]Severity of Illness Index03 medical and health sciences0302 clinical medicineRheumatologySpondylarthritisHeart rateHumansMedicineAerobic exerciseSpondylitis Ankylosing030212 general & internal medicineAxial spondyloarthritisBASDAIPhysical Therapy ModalitiesComputingMilieux_MISCELLANEOUS030203 arthritis & rheumatologyAnkylosing spondylitismedicine.diagnostic_testbusiness.industryRecovery of FunctionMiddle Agedmedicine.diseaseExercise Therapy3. Good healthTreatment OutcomeErythrocyte sedimentation rateMeta-analysisPhysical therapyFemalebusinessBASFI

description

Aim To evaluate the impact of an aerobic fitness program on disease activity, defined by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and on C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and the Bath Ankylosing Spondylitis Functional Index (BASFI) in case of axial spondyloarthritis. Methods A systematic review of the literature, following the Prisma recommendations, was performed by two reviewers on the PubMed and Embase databases. Controlled trials assessing the efficacy of aerobic exercises compared to physiotherapy on axial spondyloarthritis disease activity were included. The diagnosis of axial spondyloarthritis was meeting the New York criteria and/or the Assessment in Axial Spondyloarthritis International Working Group criteria. Aerobic fitness was defined as an exercise performed at 50%-90% of the maximal heart rate or between 50% and 80% oxygen consumption (VO2 ) peak. Results Five hundred and twenty abstracts were identified and 93 abstracts were analyzed. Eight studies met the selection criteria and 6 were finally included in this study because of the presence of a control group. Both groups were similar in terms of age, sex ratio, disease duration. Aerobic exercise provided a positive impact on the BASDAI in the intervention group (148 patients) (weighted mean difference [WMD]: -0.52 [95% CI: -0.9 to -0.13]) (I2 : 10.3%, P = 0.35). However, when compared to a control group (152 patients), the improvement of BASDAI didn't reach significance (WMD: -0.25 [95% CI: -0.83 to 0.32]) (I2 : 0%, P = 0.41). Aerobic exercise did not improve BASFI, CRP or ESR. Conclusion Aerobic exercise did not provide beneficial effects either on disease activity or on physical function and biological parameters when compared to a control group in axial spondyloarthritis.

yearjournalcountryeditionlanguage
2019-02-01International Journal of Rheumatic Diseases
https://doi.org/10.1111/1756-185x.13385