Deaths Associated with Ankylosing Spondylitis in France from 1969 to 2009.

Objective.To describe deaths for which ankylosing spondylitis (AS) was on death certificates in France.Methods.Death certificates in which AS was indicated were evaluated. Standard mortality ratio (SMR) was assessed.Results.AS appeared in 2940 death certificates. The mortality rate of AS seemed stable. The most frequent initial causes were diseases of the circulatory system [28.3% in the International Classification of Diseases, 10th ed (ICD-10)]. SMR adjusted for age and sex were 2.1 (95% CI 1.45–2.91) for infections and 0.43 (0.36–0.5) for cancers (ICD-10 period).Conclusion.This study found an increase in mortality from infectious and external causes of death; conversely, patients with AS…

Atteinte des vaisseaux dans les spondyloarthrites axiales

Resume La spondylarthrite ankylosante est un rhumatisme inflammatoire chronique caracterise par une atteinte des entheses entrainant des douleurs inflammatoires et une impotence fonctionnelle. La spondylarthrite est associee potentiellement a des manifestations extra-articulaires (uveite, psoriasis, maladie intestinale chronique inflammatoire) et des comorbidites (cardiovasculaire et osteoporose) qui en font avec l’ankylose, la gravite de cette maladie. Comme de nombreuses maladies systemiques inflammatoires, il existe une surmortalite liee a une atteinte cardiovasculaire responsable d’un sur-risque d’infarctus du myocarde, d’accidents vasculaires cerebraux et d’evenements thromboemboliques…

Visceral adiposity in patients with psoriatic arthritis and psoriasis alone and its relationship with metabolic and cardiovascular risk

Abstract Background Fat mass distribution, especially in the abdominal visceral region, has been rarely evaluated in patients with PsA or psoriasis (PsO). Methods Patients with PsA and patients with PsO alone were evaluated and compared with control subjects (1:1 ratio in each patient group) matched for age, sex and BMI category. Body composition and fat distribution (android and visceral fat) were evaluated by DXA. Anthropometric measurements, disease activity and the systematic coronary risk evaluation (SCORE) cardiovascular risk were assessed. Metabolic parameters (insulin, homeostasis model assessment for insulin resistance), serum adipokines [total and high-molecular-weight adiponectin…

Effet de la cryothérapie locale sur l’inflammation vasculaire, la dysfonction endothéliale et l’activation endothéliale en cas d’arthrite

Introduction La polyarthrite rhumatoide (PR) est caracterisee par une surmortalite d’origine cardiovasculaire, qui est la consequence d’une dysfonction et d’une activation endotheliales (infiltration vasculaire par les cellules de l’immunite), et d’une inflammation vasculaire. Ces dernieres annees, un regain d’interet pour la cryotherapie locale ou corps entier en tant que therapie d’appoint a emerge. Alors que des donnees existent en faveur d’un effet positif de la cryotherapie locale sur la douleur et l’activite de la maladie, l’effet de ce type de strategie sur le risque cardiovasculaire est pour l’instant inconnu. L’objectif de notre etude a ete d’evaluer l’effet d’un traitement par cry…

Immunogenicity of TNF alpha inhibitors in rheumatology: many questions, enough answers?

Aerobic exercise for axial spondyloarthritis - its effects on disease activity and function as compared to standard physiotherapy: A systematic review and meta-analysis

Aim To evaluate the impact of an aerobic fitness program on disease activity, defined by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and on C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and the Bath Ankylosing Spondylitis Functional Index (BASFI) in case of axial spondyloarthritis. Methods A systematic review of the literature, following the Prisma recommendations, was performed by two reviewers on the PubMed and Embase databases. Controlled trials assessing the efficacy of aerobic exercises compared to physiotherapy on axial spondyloarthritis disease activity were included. The diagnosis of axial spondyloarthritis was meeting the New York criteria and/o…