6533b85dfe1ef96bd12be6d7
RESEARCH PRODUCT
Hemmung der Adenosintriphosphatase durch Colchicin
W. EstelmannK. LangG. Siebertsubject
PharmacologyCellular and Molecular NeuroscienceContraction (grammar)PhosphataseMolecular MedicineAtpase activityCell BiologyBiologyMolecular BiologyMitosisMolecular biologyCell biologydescription
The ATPase activity is inhibited by Colchicin in concentrations of 10−3 m and 10−4 m at a rate of 40 to 20 %, but in no way in the range of 10−7 m and 10−8 m, where Colchicin exerts its typical spindle-blocking action on the mitotic cell division. It is therefore no evidence, that Colchicin acts by influence on the energy yielding ATP-ATPase system, which was proposed to be responsible for the spindle contraction.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1951-10-01 | Experientia |