Association Between Carotid Atherosclerosis and Metabolic Syndrome: Results From the ISMIR Study

6533b85dfe1ef96bd12be89e

RESEARCH PRODUCT

Association Between Carotid Atherosclerosis and Metabolic Syndrome: Results From the ISMIR Study

Francesco Antonini-canterin Antonio Pezzano Frank Benedetto Vitantonio Di Bello Francesco Perticone Giuseppe Gullace Concetta Zito Salvatore La Carrubba Scipione Carerj Salvatore Novo Alberto Balbarini Giovanni Di Salvo

subject

Blood Glucose Carotid Artery Diseases Male medicine.medical_specialty carotid intima-media thickness; carotid plaques; fibrinogen; metabolic syndrome; triglycerides carotid intima-media thickness Fibrinogen Asymptomatic chemistry.chemical_compound Risk Factors Internal medicine medicine Humans cardiovascular diseases Triglycerides Aged Metabolic Syndrome Creatinine Vascular disease business.industry carotid plaques Fibrinogen Middle Aged medicine.disease Uric Acid Cross-Sectional Studies medicine.anatomical_structure Endocrinology Italy chemistry Creatinine cardiovascular system Cardiology Uric acid Population study Female medicine.symptom Metabolic syndrome Tunica Intima Tunica Media Cardiology and Cardiovascular Medicine business medicine.drug Artery

description

The metabolic syndrome (MetS) has previously been associated with an early marker of atherosclerosis, the carotid intima-media thickness (IMT). From the ISMIR (Ispessimento Medio Intimale e Rischio cardiovascolare [media-intima thickness and cardiovascular risk]) study population of 479 asymptomatic participants, we identified 80 participants with MetS. Carotid IMT and plaques were evaluated by ultrasonography. Blood samples were obtained from all participants. Participants with MetS had a significantly higher prevalence of a carotid IMT > 0.80 mm (P = .004) and of carotid plaques (P < .001) as compared with participants without MetS. Carotid IMT was significantly correlated with fasting triglycerides and fibrinogen levels both in participants with MetS and in those without MetS (all P < .01). In contrast, IMT correlated with fasting plasma glucose, serum creatinine, and uric acid levels only in participants without MetS. Our study confirms the association between MetS and carotid atherosclerosis. In MetS, a significant correlation between carotid IMT and triglycerides and fibrinogen levels was found.

year	journal	country	edition	language
2010-01-01	Angiology

https://doi.org/10.1177/0003319709360523