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RESEARCH PRODUCT
The influence of advanced glycation endproducts (AGE) on the expression of human endothelial adhesion molecules.
T. KuntThomas ForstM. LöbigA. PfütznerO. HarzerG. BuchertE. StofftJ. BeyerM. EngelbachA. Zschäbitzsubject
Glycation End Products AdvancedTranscription GeneticEndocrinology Diabetes and MetabolismIntercellular Adhesion Molecule-1Gene ExpressionVascular Cell Adhesion Molecule-1BiologyPolymerase Chain ReactionEndocrinologyGlycationAlbuminsE-selectinInternal MedicinemedicineHumansCell adhesionMacrovascular diseaseDose-Response Relationship DrugCell adhesion moleculeGeneral MedicineAdhesionmedicine.diseaseIntercellular Adhesion Molecule-1ImmunohistochemistryEndothelial stem cellImmunologyLuminescent Measurementsbiology.proteinCancer researchEndothelium VascularE-Selectindescription
Advanced glycation endproducts (AGEs) possibly play a dominant role in the pathogenesis of macrovascular disease in diabetes. Recent studies could demonstrate that glycated albumin (AGE-BSA) was able to stimulate vascular cell adhesion molecule-1 (VCAM.1) on endothelial cells. The aim of this study was to find out if AGE-BSA was not only able to enhance the expression of vascular cell adhesion molecule-1, but also of intercellular adhesion molecule-1 (ICAM-1) and E-Selectin on human endothelial cells. Stimulation of endothelial cells with AGE-BSA for six hours predominantly increased the expression of VCAM-1, but ICAM-1 and E-Selectin were also upregulated as shown by immunoilluminometric assay (ILMA).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-08-26 | Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association |