Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants

6533b85dfe1ef96bd12bf1f8

RESEARCH PRODUCT

Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants

Provvidenza Damiani Rosalyn A. Jurjus Alice Gerges Geagea Alice Gerges Geagea Francesca Rappa Giovanni Tomasello Margherita Mazzola Abdo Jurjus Abdo Jurjus Sahar Al Kattar Francesco Carini Angelo Leone Tarek Bou-assi

subject

0301 basic medicine Cancer Research Carcinogenesis Settore MED/06 - Oncologia Medica Colorectal cancer DNA repair Cell Review Colorectal Neoplasm medicine.disease_cause Antioxidants 03 medical and health sciences 0302 clinical medicine Antioxidants; Colorectal cancer; Dysbiosis; Oxidative stress; Review; Animals; Antioxidants; Carcinogenesis; Colorectal Neoplasms; Humans; Reactive Oxygen Species; Oxidative Stress; Oncology; Cancer Research Animals Humans Medicine colorectal cancer dysbiosis microbioma oxodative stress carcinogenesi Carcinogenesi chemistry.chemical_classification Reactive oxygen species Animal business.industry Oxidative Stre General Medicine Colorectal carcinogenesis medicine.disease Colorectal cancer Dysbiosi Oxidative Stress Settore MED/18 - Chirurgia Generale colorectal cancer dysbiosis microbioma oxodative stress carcinogenesis 030104 developmental biology medicine.anatomical_structure Oncology Biochemistry chemistry 030220 oncology & carcinogenesis Cancer research Antioxidant Colorectal Neoplasms Reactive Oxygen Species Reactive Oxygen Specie business Carcinogenesis Dysbiosis Oxidative stress Human

description

One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documented the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yield definitive results and were performed mostly in vitro on cell populations, or in vivo in experimental animal models.

year	journal	country	edition	language
2017-01-01	Anticancer Research

https://doi.org/10.21873/anticanres.11882