Circulating miR-99a-5p Expression in Plasma: A Potential Biomarker for Early Diagnosis of Breast Cancer

6533b85dfe1ef96bd12bf2c9

RESEARCH PRODUCT

Circulating miR-99a-5p Expression in Plasma: A Potential Biomarker for Early Diagnosis of Breast Cancer

Anna Adam-artigues Ana Lluch Pilar Eroles Rui Henrique Begoña Bermejo Soraya Simón Ana Lameirinhas Belen Ortega Carmen Jerónimo Paula Lopes Iris Garrido-cano Cristina Hernando Vera Constâncio M. I. Martínez Juan Miguel Cejalvo

subject

Oncology medicine.medical_specialty diagnosis Down-Regulation Breast Neoplasms Real-Time Polymerase Chain Reaction Article Catalysis lcsh:Chemistry Inorganic Chemistry breast cancer Breast cancer Internal medicine microRNA Biomarkers Tumor Humans Medicine Diagnostic biomarker Circulating MicroRNA Physical and Theoretical Chemistry skin and connective tissue diseases lcsh:QH301-705.5 Molecular Biology Early Detection of Cancer plasma Spectroscopy Retrospective Studies Early breast cancer Plasma samples business.industry Organic Chemistry General Medicine Middle Aged medicine.disease Computer Science Applications Gene Expression Regulation Neoplastic MicroRNAs ROC Curve lcsh:Biology (General)lcsh:QD1-999 Potential biomarkers Cohort biomarker Biomarker (medicine)Female business

description

MicroRNAs have emerged as new diagnostic and therapeutic biomarkers for breast cancer. Herein, we analysed miR-99a-5p expression levels in primary tumours and plasma of breast cancer patients to evaluate its usefulness as a minimally invasive diagnostic biomarker. MiR-99a-5p expression levels were determined by quantitative real-time PCR in three independent cohorts of patients: (I) Discovery cohort: breast cancer tissues (n = 103) and healthy breast tissues (n = 26)

year	journal	country	edition	language
2020-10-08	International Journal of Molecular Sciences

https://doi.org/10.3390/ijms21197427

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