6533b85efe1ef96bd12bf3b9
RESEARCH PRODUCT
In vivo genotoxicity of selected herbicides in the mouse bone-marrow micronucleus test
Sebastian KevekordesR. EdenharderGebel TK. PavHartmut Dunkelbergsubject
MaleHealth Toxicology and Mutagenesis010501 environmental sciencesPharmacologyToxicologymedicine.disease_cause01 natural sciencesToxicologyMice03 medical and health scienceschemistry.chemical_compoundBone MarrowIn vivomedicineAnimalsAtrazine030304 developmental biology0105 earth and related environmental sciences0303 health sciencesMicronucleus TestsHerbicidesAlachlorTrifluralinGeneral MedicineTerbuthylazinechemistryToxicityMicronucleus testFemaleGenotoxicityMutagensdescription
The herbicides alachlor, atrazine, terbuthylazine, gluphosinate-ammonium, isoproturon, pendimethaline and trifluralin were tested for genotoxicity in the mouse bone-marrow micronucleus test (MNT). Both atrazine and trifluraline caused a significant increase in the number of micronuclei at doses of 1,400 mg/kg body weight in female mice only. Alachlor, terbuthylazine, gluphosinate-ammonium, isoproturon and pendimethaline did not have any genotoxic effect in the mouse bone-marrow micronucleus test in either female or male animals.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-01-30 | Archives of Toxicology |