6533b85efe1ef96bd12bfd77
RESEARCH PRODUCT
A Bioinspired Dinickel(II) Hydrolase: Solvent Vapor-Induced Hydrolysis of Carboxyesters under Ambient Conditions
Rabindra Nath MukherjeeRabindra Nath MukherjeeSuman K. BarmanFrancesc Lloretsubject
HydrolasesInorganic chemistryEthyl acetatechemistry.chemical_elementCrystallography X-Ray010402 general chemistry01 natural sciencesInorganic Chemistrychemistry.chemical_compoundHydrolysisNickelPolymer chemistryHydrolaseMoleculeBound waterPhysical and Theoretical Chemistry010405 organic chemistryHydrolysisSubstrate (chemistry)Esters0104 chemical sciencesSolventNickelchemistryPotentiometrySolventsdescription
From the perspective of synthetic metallohydrolases, a phenoxo-bridged dinickel(II) complex [NiII2(L)(H2O)2(CH3OH)][ClO4]·CH3OH (1) (H3L = 2,6-bis[{{(5-bromo-2-hydroxybenzyl)(N′,N″-(dimethylamino)ethyl)}amino}methyl]-4-methylphenol) has been synthesized and structurally characterized. The presence of a vacant coordination site and a weakly bound water molecule provides the scope for substrate binding to act as a metallohydrolase model. Ethyl acetate vapor diffusion at 298 K to a CH3CN/CH3OH solution of 1 results in the formation of a pentanuclear acetato-bridged complex [NiII5(H2L)2(μ3-OH)2(μ-O2CCH3)4][ClO4]2·CH3CO2C2H5 (2), demonstrating for the first time the metal-coordinated water-promoted hydrolysis of a carboxyester at room temperature. When the crystals of 1, moistened with a few drops of ethyl acetate, were kept for ethyl acetate vapor diffusion, it transforms into a monoacetato-bridged complex [NiII2(HL)(μ-O2CCH3)(H2O)2][ClO4]·4H2O (3). This kind of solvent (vapor)-induced single-crystal-to-singl...
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-12-08 | Inorganic Chemistry |