6533b85efe1ef96bd12c0510
RESEARCH PRODUCT
The Effect of 5-Aminosalicylic Acid on Intestinal Microbiota
Vizma NikolajevaIneta KalniņaIda JākobsoneAleksejs DerovsVanda SargautieneRenāte Ligeresubject
0301 basic medicine03 medical and health scienceschemistry.chemical_compound030104 developmental biology0302 clinical medicineAminosalicylic acidChemistry030211 gastroenterology & hepatologyPharmacologydigestive systemdescription
Abstract The article discusses the possible relationships between intestinal microbiota and the therapeutic efficacy of 5-aminosalicylic acid (5-ASA) in inflammatory bowel diseases. Intestinal microbiota may be involved in 5-ASA enzymatic biotransformation, but the metabolism of drugs by the intestinal microbiota has been studied in less detail, and little is known about the relationships between anti-inflammatory efficacy of 5-ASA with bacterial viability, quantity and activity. It remains unclear whether 5-ASA affects the microbiota depending on the different segments of gastrointestinal tract. Drugs and diet can both improve and worsen the composition of the intestinal microbiota. However, it is not known whether drugs affect the intestinal microbiota regardless of diet. Further research is needed to answer these questions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-04-01 | Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. |