6533b85efe1ef96bd12c0545

RESEARCH PRODUCT

PHOSPHORORGANISCHE VERBINDUNGEN 1091DIE SYNTHESE FLUORESZIERENDER REAGENTIEN MIT CHEMOSELEKTIVEN ANKERGRUPPEN

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Abstract A route for the synthesis of type B-compounds is reported. Compound 5 is a strong fluorescent and is O-selective. Type C-compounds, for example 10a to 10d show a high fluorescence and are O-selective. They are obtained via 6 and 7 (n=2–4,6; R=Me, X=F). Boc-serine is O-phosphonylated by the methyl-phosphonicacid-esterfluorides, for example 10c. ω-(9-Acridinyl)alkyl-phosphonicacid-alkyl-esterfluorides, like 22, are available in only moderate yields via 15a-e as intermediates. More but unsuccessful experiments for the synthesis of fluorescent and O-selective acridine compounds are reported shortly. Die Synthese von Verbindungen vom Typ B wird beschrieben. Die Verbindung 5 verbindet Fluoreszenz mit O-Selektivitat. Verbindungen vom Typ C, z.B. 10a bis 10d, fluoreszieren stark und sind O-selektiv. Sie werden erhalten uber die Zwischenstufen 6 und 7 (n=2–4, 6; R=Me, X=F). Boc-Serin wird durch diese Methylphosphonsaureesterfluoride. z.B. 10c, O-phosphonyliert. ω-(9-Acridinyl)alkyl-phosphon-saure-alkylest...