P-77D-PENICILLAMINE, A POTENTIAL ETHANOL ANTI-RELAPSE DRUG, DOES NOT REDUCE THE VOLUNTARY ETHANOL INTAKE IN LONG-TERM EXPERIENCED RATS

6533b85efe1ef96bd12c0564

RESEARCH PRODUCT

P-77D-PENICILLAMINE, A POTENTIAL ETHANOL ANTI-RELAPSE DRUG, DOES NOT REDUCE THE VOLUNTARY ETHANOL INTAKE IN LONG-TERM EXPERIENCED RATS

Alejandro Orrico M. J. Cano-cebrián B. Cabañero Teodoro Zornoza Lucía Martí-prats F. B. Gosálbez

subject

Drug Ethanol business.industry media_common.quotation_subject Penicillamine Acetaldehyde General Medicine Pharmacology chemistry.chemical_compound chemistry Biochemistry medicine Ethanol intake business medicine.drug media_common

description

Experimental evidence has demonstrated that the reinforcing effects of ethanol crucially depend on the brain formation of acetaldehyde (ACD). Rationally supported by this basis, we previously evaluated a novel strategy to prevent relapse in alcoholism based on chemical ACD inactivation using D-Penicillamine (DP). Under our experimental …

year	journal	country	edition	language
2015-09-01	Alcohol and Alcoholism

https://doi.org/10.1093/alcalc/agv080.77

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