6533b85efe1ef96bd12c0688
RESEARCH PRODUCT
Novel two-step synthesis of gold nanoparticles capped with bile acid conjugates
Virpi NoponenElina SievänenShreedhar BhatErkki Kolehmainensubject
Lithocholic acidBile acidChemistryLigandmedicine.drug_classBioengineeringBiomaterialschemistry.chemical_compoundUltraviolet visible spectroscopyMechanics of MaterialsColloidal goldYield (chemistry)medicineMoleculeOrganic chemistryConjugatedescription
Bile acids and their conjugates are physiologically important molecules. Syntheses and structure elucidation combined with investigation of properties and applications of bile acids and their derivatives are of academic interest. The concept of using bile acids and their conjugates in nanoscience is a novel idea, which opens up fascinating prospects. In this article, an easy and simple route for obtaining N-lithocholyl-L-(cysteine ethyl ester) (3), capable of effectively capping and stabilizing metal nanoparticles, is described. The whole synthetic route needs only two steps giving a moderate to good yield. The gold NPs are characterized by elemental analysis, UV spectroscopy, and TEM. Additionally, $^{13}C$ CP/MAS NMR studies for different ligand/Au ratios have been performed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-08-01 | Materials Science and Engineering: C |