AFM study of interaction forces in supported planar DPPC bilayers in the presence of general anesthetic halothane

6533b85efe1ef96bd12c06e6

RESEARCH PRODUCT

AFM study of interaction forces in supported planar DPPC bilayers in the presence of general anesthetic halothane

Eric Finot Zoya Leonenko David T. Cramb

subject

1 2-Dipalmitoylphosphatidylcholine Microdomains Kinetics Lipid Bilayers Biophysics 02 engineering and technology 010402 general chemistry Microscopy Atomic Force 01 natural sciences Biochemistry chemistry.chemical_compound Planar bilayer medicine Lipid bilayer Chemistry Bilayer Force spectroscopy Cell Biology 021001 nanoscience & nanotechnology Force spectroscopy 0104 chemical sciences Crystallography Kinetics Membrane [ PHYS.PHYS.PHYS-AO-PH ] Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph]Chemical physics Dipalmitoylphosphatidylcholine Anesthetic Anesthetics Inhalation Halothane 0210 nano-technology Halothane medicine.drug

description

International audience; In spite of numerous investigations, the molecular mechanism of general anesthetics action is still not well understood. It has been shown that the anesthetic potency is related to the ability of an anesthetic to partition into the membrane. We have investigated changes in structure, dynamics and forces of interaction in supported dipalmitoylphosphatidylcholine (DPPC) bilayers in the presence of the general anesthetic halothane. In the present study, we measured the forces of interaction between the probe and the bilayer using an atomic force microscope. The changes in force curves as a function of anesthetic incorporation were analyzed. Force measurements were in good agreement with AFM imaging data, and provided valuable information on bilayer thickness, structural transitions, and halothane-induced changes in electrostatic and adhesive properties.

year	journal	country	edition	language
2006-04-01	Biochimica et Biophysica Acta (BBA) - Biomembranes

10.1016/j.bbamem.2006.02.033 http://dx.doi.org/10.1016/j.bbamem.2006.02.033

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