Chemical modification of halloysite nanotubes for controlled loading and release.

6533b85efe1ef96bd12c0746

RESEARCH PRODUCT

Chemical modification of halloysite nanotubes for controlled loading and release.

Renato Noto Giuseppe Lazzara Serena Riela Marina Massaro Stefana Milioto Giuseppe Cavallaro Carmelo Giuseppe Colletti

subject

Nanotube Materials science Tunable properties Controlled drug delivery Halloysite nanotube Biomedical Engineering Supramolecular chemistry Nanotechnology 02 engineering and technology engineering.material Chemical characteristic 010402 general chemistry Yarn Biologically active molecule 01 natural sciences Halloysite Nanomaterials Aluminosilicate Kaolinite General Materials Science Functionalization Gene transfer Settore CHIM/02 - Chimica Fisica Targeted drug delivery Covalent modification Molecule General Chemistry General Medicine Settore CHIM/06 - Chimica Organica 021001 nanoscience & nanotechnology 0104 chemical sciences Nanostructured material Nanotube Self-healing hydrogels engineering Tissue regeneration Surface modification Clay 0210 nano-technology Drug carrier Hybrid nanomaterial Chemical modification Covalent grafting

description

Clay minerals have been used for medical purposes from ancient times. Among them, the halloysite nanotube, an aluminosilicate of the kaolin group, is an emerging nanomaterial which possesses peculiar chemical characteristics. By means of suitable modifications, such as supramolecular functionalization or covalent modifications, it is possible to obtain novel nanomaterials with tunable properties for several applications. In this context the covalent grafting of suitable organic moieties on the external surface or in the halloysite lumen has been exploited to improve the loading and release of several biologically active molecules. The resulting hybrid nanomaterials have been applied as drug carrier and delivery systems, as fillers for hydrogels, in tissue regeneration and in the gene delivery field. Furthermore the loading and release of specific molecules have been also investigated for environmental purposes. This review summarizes the main developments in the halloysite modifications in the last 20 years with a particular attention to the development in the past two years.

year	journal	country	edition	language
2020-04-08	Journal of materials chemistry. B

10.1039/c8tb00543e https://pubmed.ncbi.nlm.nih.gov/32254440