6533b85efe1ef96bd12c089f
RESEARCH PRODUCT
Cooperative Assistance in Bifunctional Organocatalysis: Enantioselective Mannich Reactions with Aliphatic and Aromatic Imines
Nicolas ProbstArto ValkonenKari RissanenPetri M. PihkoÁDám MadarászImre PápaiAntti J. Neuvonensubject
Models MolecularHydrogen bond catalysisImineEnantioselective synthesisHydrogen BondingStereoisomerismGeneral MedicineGeneral ChemistryCrystallography X-RayMalonatesCatalysisCatalysischemistry.chemical_compoundchemistryNucleophileOrganocatalysisPolymer chemistryOrganic chemistryMoietyIminesAmino AcidsBifunctionalta116description
both of which contain a thiourea moiety (Scheme 1).The catalysts are capable of deprotonating suitable nucleo-philes, such as activated carbonyl compounds. This proton-transfer reaction generates an ion pair, which is composed ofthe protonated catalyst and the anionic nucleophile interact-ing through hydrogen bonds. At least one of the NH moietiesin the protonated catalyst is involved in activating theelectrophilic reaction partner.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-07-09 | Angewandte Chemie International Edition |