Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer

6533b85ffe1ef96bd12c11f1

RESEARCH PRODUCT

Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer

Julie Vincent François Ghiringhelli Bruno Chauffert Pablo Ortega-deballon Séverine Guiu Sylvain Ladoire Guiu Boris Jean-pierre Cercueil

subject

Oncology Male [SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery Organoplatinum Compounds Colorectal cancer medicine.medical_treatment Case Report Deoxycytidine Metastasis chemistry.chemical_compound 0302 clinical medicine Hepatic Artery Antineoplastic Combined Chemotherapy Protocols [ SDV.MHEP.CHI ] Life Sciences [q-bio]/Human health and pathology/Surgery 0303 health sciences Liver Neoplasms Gastroenterology virus diseases General Medicine Middle Aged Magnetic Resonance Imaging 3. Good health Oxaliplatin Treatment Outcome 030220 oncology & carcinogenesis Colonic Neoplasms Catheter Ablation Adenocarcinoma Deoxycytidine medicine.drug medicine.medical_specialty animal structures [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery Adenocarcinoma 03 medical and health sciences Hepatic arterial infusion Internal medicine medicine Humans Infusions Intra-Arterial 030304 developmental biology Chemotherapy business.industry medicine.disease Gemcitabine Gemcitabine Oxaliplatin chemistry business Tomography X-Ray Computed

description

International audience; Hepatic arterial infusion (HAI) of chemotherapy can be performed in cases of liver-confined metastatic disease, resulting in increased local drug concentrations. Here we report the case of a 61-year-old man who presented with an isolated large unresectable liver metastasis of colon cancer after failure of surgery and multiple administration of systemic chemotherapy. The patient was treated with a combination of gemcitabine and oxaliplatin using HAI. The tolerance was excellent and a radiological complete response was obtained after 8 cycles of HAI. The rationale for the use of gemcitabine and oxaliplatin as well as that for the combination of the 2 drugs is discussed in this paper. HAI of gemcitabine-oxaliplatin should be evaluated in further clinical trials.

year	journal	country	edition	language
2010-03-07

10.3748/wjg.v16.i9.1150 https://europepmc.org/articles/PMC2835794/

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