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RESEARCH PRODUCT
The Impact of Hormone Therapy on Health
María Dolores JuliáAntonio CanoTommaso SimonciniTomi S. MikkolaEsperanza Navarro-pardoMarta Millánsubject
business.industrymedicine.drug_classmedicine.medical_treatmentUterusPhysiologyLuteal phaseEndometriummedicine.anatomical_structuremedicineMenopausal SymptomHormone therapyReceptorbusinessProgestinhormones hormone substitutes and hormone antagonistsHormonedescription
Hormone therapy (HT) has menopausal symptom control as the main indication. However, and because estrogens have receptors spread over many systems in the body, the use of hormones may have consequences on health. Hormone therapy consists of estrogens essentially, since menopausal symptoms mainly derive from estrogen deprivation at different target tissues. However, the normal ovarian cycle includes the regular secretion of progesterone during the days of the luteal phase. Progesterone has a neutralizing effect over endometrial proliferation, this being the reason for adding progestogens to HT formulations in order to protect endometrium. So, guidelines recommend that women with uterus use estrogen plus progestogens, which may be combined in different forms. And because of that, the impact of HT on health should also consider the specific effects of both estrogens and progestogens in addition to those of only estrogens. While this has turned to be of minor importance in some areas, it is not so in others, like for example the oncological risk.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 |