Artesunate Inhibits Growth of Sunitinib-Resistant Renal Cell Carcinoma Cells through Cell Cycle Arrest and Induction of Ferroptosis

6533b85ffe1ef96bd12c1c40

RESEARCH PRODUCT

Artesunate Inhibits Growth of Sunitinib-Resistant Renal Cell Carcinoma Cells through Cell Cycle Arrest and Induction of Ferroptosis

Rene Mager Kimberly S. Slade Axel Haferkamp Thomas A. Efferth Sascha D. Markowitsch Eva Juengel Julia Lauckner Patricia Schupp Olesya Vakhrusheva

subject

0301 basic medicine Cancer Research Traditional Chinese Medicine (TCM) growth inhibition ferroptosis reactive oxygen species (ROS)Cell cycle checkpoint Biology urologic and male genital diseases reactive oxygen species (ROS)lcsh:RC254-282 Article growth inhibition 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine renal cell carcinoma (RCC)medicine Clonogenic assay Cytotoxicity artesunate (ART)Sunitinib Traditional Chinese Medicine (TCM)Cell cycle lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ferroptosis sunitib resistance 030104 developmental biology Oncology chemistry Cell culture Apoptosis 030220 oncology & carcinogenesis Cancer research Growth inhibition medicine.drug

description

Although innovative therapeutic concepts have led to better treatment of advanced renal cell carcinoma (RCC), efficacy is still limited due to the tumor developing resistance to applied drugs. Artesunate (ART) has demonstrated anti-tumor effects in different tumor entities. This study was designed to investigate the impact of ART (1&ndash

year	journal	country	edition	language
2020-10-27	Cancers

10.3390/cancers12113150 https://www.mdpi.com/2072-6694/12/11/3150

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