Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments.

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RESEARCH PRODUCT

Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments.

Pieter J. Vuijk Isabella Vainieri Jonna Kuntsi Alysa E. Doyle Russell Schachar Kirstin L. Purves Bru Cormand Stephen V. Faraone Barbara Franke Anna-sophie Rommel Jennifer Crosbie Marta Ribasés Jan K. Buitelaar Sandra K. Loo Herbert Roeyers Joanna Martin Ana Miranda Aribert Rothenberger Philip Asherson Hans-christoph Steinhausen Tobias Banaschewski Joseph A. Sergeant Iris Manor Robert D. Oades J. Antoni Ramos-quiroga

subject

cognition Trastorns per dèficit d'atenció amb hiperactivitat en els infants Medizin Social Sciences Genome-wide association study Attention deficit disorder with hyperactivity in children 3202 Applied Psychology 2738 Psychiatry and Mental Health 0302 clinical medicine Atenció DUPLICATIONS 2.1 Biological and endogenous factors Psychology Aetiology Genetic risk Child POPULATION Applied Psychology Response inhibition Psychiatry REACTION-TIME VARIABILITY Cognition 10058 Department of Child and Adolescent Psychiatry inhibition Psychiatry and Mental health Phenotype Mental Health polygenic risk scores reaction time variability Cognició Public Health and Health Services /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being Trastorns per dèficit d'atenció amb hiperactivitat en els adults RESPONSE-INHIBITION Clinical psychology Adult Adolescent DEFICIT HYPERACTIVITY DISORDER 610 Medicine & health GENETIC RISK behavioral disciplines and activities Young Adult 03 medical and health sciences WORKING-MEMORY SDG 3 - Good Health and Well-being mental disorders Reaction Time Genetics medicine Humans Attention deficit hyperactivity disorder ADHD Cognitive Dysfunction GENOME-WIDE ASSOCIATION Association (psychology)business.industry Prevention Human Genome Neurosciences Genetic variants PERFORMANCE medicine.disease Attention Deficit Hyperactivity Disorder (ADHD)030227 psychiatry attention Attention Deficit Disorder with Hyperactivity Inhibició Case-Control Studies Attention deficit disorder with hyperactivity in adults Polygenic risk score business 030217 neurology & neurosurgery Genome-Wide Association Study

description

AbstractBackgroundA recent genome-wide association study (GWAS) identified 12 independent loci significantly associated with attention-deficit/hyperactivity disorder (ADHD). Polygenic risk scores (PRS), derived from the GWAS, can be used to assess genetic overlap between ADHD and other traits. Using ADHD samples from several international sites, we derived PRS for ADHD from the recent GWAS to test whether genetic variants that contribute to ADHD also influence two cognitive functions that show strong association with ADHD: attention regulation and response inhibition, captured by reaction time variability (RTV) and commission errors (CE).MethodsThe discovery GWAS included 19 099 ADHD cases and 34 194 control participants. The combined target sample included 845 people with ADHD (age: 8–40 years). RTV and CE were available from reaction time and response inhibition tasks. ADHD PRS were calculated from the GWAS using a leave-one-study-out approach. Regression analyses were run to investigate whether ADHD PRS were associated with CE and RTV. Results across sites were combined via random effect meta-analyses.ResultsWhen combining the studies in meta-analyses, results were significant for RTV (R2 = 0.011, β = 0.088, p = 0.02) but not for CE (R2 = 0.011, β = 0.013, p = 0.732). No significant association was found between ADHD PRS and RTV or CE in any sample individually (p > 0.10).ConclusionsWe detected a significant association between PRS for ADHD and RTV (but not CE) in individuals with ADHD, suggesting that common genetic risk variants for ADHD influence attention regulation.

year	journal	country	edition	language
2022-10-01	Psychological medicine

10.1017/s0033291720005218 https://pubmed.ncbi.nlm.nih.gov/33531098